化合物Aldoxorubicin盐酸盐 T11090L1

Product Introduction
Bioactivity


英文名: Aldoxorubicin hydrochloride

描述: Aldoxorubicin hydrochloride 是 Doxorubicin (DNA 拓扑异构酶 II 抑制剂) 的白蛋白结合前药。Aldoxorubicin hydrochloride 在酸性条件下从白蛋白中释放出来。 Aldoxorubicin hydrochloride 显示出有效的抗肿瘤活性。

体外活性: Aldoxorubicin hydrochloride (0.27 to 2.16 μM) inhibits formation of blood vessel and reduces growth of multiple myeloma cell in a pH-dependent fashion[1].

体内活性: Aldoxorubicin hydrochloride (10.8 mg/kg, i.v.) exhibits significantly smaller tumor volumes and IgG levels on days 28, and is well tolerated with 90% of mice surviving until the termination of the study in the mice bearing the LAGκ-1A tumor[1]. Aldoxorubicin hydrochloride exhibits a good safety profile at doses up to 260 mg/mL doxorubicin equivalents, and is able to induce tumor regressions in breast cancer, small cell lung cancer and sarcoma in phase I study[2]. Aldoxorubicin hydrochloride exhibits superior activity over doxorubicin in a murine renal cell carcinoma model and in breast carcinoma xenograft models[3].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 7.87 mg/mL (10 mM)


关键字: Aldoxorubicin Hydrochloride | 1361644-26-9 Free base | 1361644-26-9

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