盐酸美克洛嗪 T1110

Product Introduction
Bioactivity


英文名: Meclizine dihydrochloride

描述: Meclizine dihydrochloride (NSC28728) 是一种组胺 H1 拮抗剂，用于治疗妊娠期间的晕动病、眩晕和恶心以及放射病。它是小鼠组成型雄甾烷受体激动剂，是人 CAR 的反向激动剂。它可透过血脑屏障，可用于多聚谷氨酰胺毒性障碍方面的研究。

细胞实验: HepG2 cells are cultured in 24-well dishes with DMEM supplemented with 10% charcoal-stripped calf serum. Cells are transfected using calcium phosphate with 100 ng of receptor expression vectors, 300 ng of luciferase reporter plasmids, and 100 ng of pSV2-β-galactosidase as internal control of transfection efficiency. Drugs are added 12 h after transfection, and cells are incubated for an additional 24 h. The cell lysate is assayed for luciferase activity and normalized to β-galactosidase activity.(Only for Reference)

体外活性: Meclizine以CAR依赖的方式增加小鼠CAR靶基因的表达.

体内活性: Meclizine在体外实验中,剂量依赖性增加mCAR反式激活,激活激素受体共激活因子1与受体的结合。相反,Meclizine在来源于小鼠的只表达hCAR,不表达mCAR的肝脏细胞中,抑制hCAR转录激活和鲁米那诱导的CAR下游基因（包括细胞色素p450 单氧酶2B10、CYP3A11以及CYP1A2）的表达。Meclizine是小鼠CAR激动剂配体(组成型雄甾烷受体),人类CAR的反向激动剂。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 15 mg/mL (32.34 mM)


关键字: Meclizine dihydrochloride | sickness | Inhibitor | Huntington | Meclozine Dihydrochloride | Apoptosis | Meclozine | anti-motion | NSC-28728 | piperazine | Meclizine Dihydrochloride | Histamine Receptor | NSC 28728 | Meclizine | antihistamine | inhibit

相关产品: PP5-IN-1 | 14-Deoxyandrographolide | BX-912 | Tetrahydropalmatine | NU 7026 | Picroside II | ZLDI-8 | DPN | C188-9 | Tandutinib

相关库: Anti-Neurodegenerative Disease Compound Library | Drug Repurposing Compound Library | Approved Drug Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | GPCR Compound Library | Inhibitor Library | Anti-Obesity Compound Library | Anti-Cancer Approved Drug Library | Apoptosis Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途