化合物 T11238 T11238

Product Introduction
Bioactivity


英文名: Etamicastat

描述: Etamicastat can be used in the research of cardiovascular diseases. Etamicastat (BIA 5-453) is a potent and reversible dopamine-β-hydroxylase (DBH) inhibitor with an IC50 value of 107 nM.

体外活性: Etamicastat blocks the hERG current amplitude with an IC50 value of 44 μg/mL.

体内活性: Etamicastat (50 mg/kg;?a single oral administration) exhibits moderate oral bioavailability (64%), Cmax (4.9 nM), and terminal elimination half-lives (T1/2=3.7 h) in male Wistar rats.Etamicastat (100 mg/kg; administered intraperitoneally) leads to a significant reduction of noradrenaline levels in heart with concomitant increasing in dopamine levels.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Etamicastat

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途