化合物 T11272 T11272

Product Introduction
Bioactivity


英文名: Fenmetozole Tosylate

描述: Fenmetozole Tosylate , acts as an antidepressant drug. is an antagonist of the actions of ethanol, also antagonizes α2-adrenergic receptor,

体外活性: Fenmetozole acts as an antagonist of α2-adrenergic receptor.

体内活性: fenmetozole attenuates the ethanol-induced reduction in cerebellar cyclic guanosine monophosphate content, but it significantly elevates cGMP levels in this tissue.?Fenmetozole does not change ethanol induced increases in punished drinking in a conflict test, but when given at a high dose, fenmetozole decreases both punished and unpunished responding.?Fenmetozole fails to precipitate ethanol withdrawal-like reactions when it is given to physically-dependent, intoxicated rats.?Fenmetozole (15-30 g/kg) reduces ethanol-induced impairment of the aerial righting reflex without altering blood or brain ethanol content.?Fenmetozole alone has no ffect on punished drinking and does not alter ethanol action in the paradigm except at the highest dose tested (30 mg/kg) in rats.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Fenmetozole Tosylate

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