化合物 T11302 T11302

Product Introduction
Bioactivity


英文名: Flumexadol

描述: Flumexadol is a selective and affinity 5-HT2C receptor agonist with a Ki of 25 nM for the (+)-enantiomer of Flumexadol, and is 40-fold selective over the 5-HT2A receptor. Flumexadol is an orally active non-narcotic analgesic.

体内活性: In rats and dogs dosed with 14C-Flumexadol (CERM1841), the 14C is excreted in the urine.?The 14C eliminated in the faeces of dog is significantly higher than for rat.?Conjugated metabolites, mostly glucuronides, accounted for the greater part of the urinary radioactivity in both species.?Biotransformation products are predominantly acids in both species, follows by significant amounts of basic metabolites, with very little neutral substances.?The major urinary metabolite in rats is 3-trifluoromethylbenzoic acid and 3-trifluoromethylhipuric acid.?In the dog it is 3-trifluoromethylmandelic acid in addition to the benzoic acid and its conjugate.?The basic products identified in the urine of both species are unchanged drug and 1-amino-2-hydroxy-2-(3-trifluoromethylphenyl)ethane, with the first predominating.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 100 mg/mL (432.51 mM)


关键字: Flumexadol

相关产品: ATC 0175 hydrochloride | Harmine | BRL-15572 dihydrochloride | (Rac)-Norcisapride | NGB 2904 | Harmine hydrochloride | Mosapride Citrate | 5-HT3-In-1 | Maprotiline hydrochloride | 5HT6-ligand-1

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途