化合物 T11378L T11378L

Product Introduction
Bioactivity


英文名: GDC-0834 Racemate

描述: GDC-0834 Racemate is the racemate form of GDC-0834, which is an effective and selective BTK inhibitor

体外活性: GDC-0834 inhibited BTK (IC50s: 5.9 and 6.4 nM in biochemical and cellular assays) and (IC50s: 1.1 and 5.6 μM in mouse and rat) [1].

体内活性: Administration of GDC-0834 (30-100 mg/kg) in a rat collagen-induced arthritis (CIA) model resulted in a dose-dependent decrease of ankle swelling and reduction of morphologic pathology [1]. GDC-0834 exhibited low clearance in PXB chimeric mice with humanized liver. GDC-0834 plasma concentrations in humans were below the limit of quantitation (<1 ng/ml) in most samples from the cohorts dosed orally at 35 and 105 mg [2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 49 mg/mL (82.11 mM)


关键字: GDC-0834 Racemate | GDC 0834 Racemate | GDC0834 Racemate

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途