化合物 T11502 T11502
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 872599-83-2 | ¥15,000.00 | 询底价 |
50 mg | 872599-83-2 | ¥19,800.00 | 询底价 |
100 mg | 872599-83-2 | ¥25,500.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Epelsiban
描述: Epelsiban is a selective and orally bioavailable oxytocin receptor antagonist (pKi: 9.9 for human oxytocin receptor).
体外活性: Epelsiban , shows no significant P450 inhibition.?is a potent oxytocin receptor, with a pKi of 9.9 for human oxytocin receptor, >31000-fold selectivity over all three human vasopressin receptors hV1aR (pKi, <5.2), hV2R (pKi, <5.1), and hV1bR (pKi, 5.4).
体内活性: Epelsiban has low levels of intrinsic clearance against the microsomes of rat, dog, and cynomolgus monkey, good bioavailability (55%), but is negative in the genotoxicity screens with a satisfactory oral safety profile in female rats.Epelsiban shows an IC50 of 192 nM for oxytocin receptor in rats.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: GSK-557296 | GSK557296 | Epelsiban
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途