化合物Encequidar mesylate T11578L
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 849675-87-2 | ¥1,690.00 | 询底价 |
1 mL | 849675-87-2 | ¥788.00 | 询底价 |
1 mg | 849675-87-2 | ¥281.00 | 询底价 |
50 mg | 849675-87-2 | ¥2,890.00 | 询底价 |
5 mg | 849675-87-2 | ¥663.00 | 询底价 |
100 mg | 849675-87-2 | ¥4,330.00 | 询底价 |
500 mg | 849675-87-2 | ¥9,360.00 | 询底价 |
10 mg | 849675-87-2 | ¥913.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Encequidar mesylate
描述: Encequidar mesylate (HM30181A mesylate) 是竞争性有效的 P-糖蛋白抑制剂。
体外活性: Treatment of 0.1 or 1 nM Encequidar lead to 20 and 42% inhibition of survival at the 100 nM and 1000 nM NSC 125973 treatment, respectively [2].
体内活性: The plasma concentrations of Encequidar are higher for the simultaneous administration with the microcapsule than with the powder; providing significant differences from 1 to 2 h. The microcapsule has about a 1.7-fold faster Tmax and a 1.6-fold higher AUC value compared with the powder (2.5±0.6 vs. 4.3±0.9 h; 107.7±20.1 vs. 64.3±18.0 h ng/mL). The faster and overall improved absorption of Encequidar in microcapsule form might be due to the remarkable enhancement of the aqueous solubility and dissolution resulting from its crystalline conversion to the amorphous form and particle size reduction [1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 55 mg/mL (70.08 mM)
关键字: HM30181A | HM 30181 Mesylate | HM30181 Mesylate | HM 30181 | Encequidar Mesylate | Encequidar mesylate | HM30181 | MDR1 | ABCB1 | HM-30181 Mesylate | P-gp | inhibit | CD243 | P-glycoprotein | Cluster of differentiation 243 | HM-30181 | Inhibitor | HM30181A Mesylate | Encequidar | Pgp | Multidrug resistance protein 1
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相关库: Drug Repurposing Compound Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Clinical Compound Library | Membrane Protein-targeted Compound Library | Neuronal Signaling Compound Library | Inhibitor Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Active Compound Library | NO PAINS Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途