化合物IBR2 T11600
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mg | 313526-24-8 | ¥398.00 | 询底价 |
500 mg | 313526-24-8 | ¥14,500.00 | 询底价 |
5 mg | 313526-24-8 | ¥879.00 | 询底价 |
25 mg | 313526-24-8 | ¥3,480.00 | 询底价 |
50 mg | 313526-24-8 | ¥5,130.00 | 询底价 |
10 mg | 313526-24-8 | ¥1,530.00 | 询底价 |
100 mg | 313526-24-8 | ¥7,270.00 | 询底价 |
2 mg | 313526-24-8 | ¥572.00 | 询底价 |
1 mL | 313526-24-8 | ¥897.00 | 询底价 |
Product Introduction
Bioactivity
英文名: IBR2
描述: IBR2 (Isoquinoline) is a potent and specific RAD51 inhibitor known for its ability to suppress RAD51-mediated DNA double-strand break repair. By interfering with RAD51 multimerization, accelerating proteasome-mediated RAD51 protein degradation, inhibiting cancer cell growth, and inducing apoptosis, IBR2 has proved to be an effective compound in these aspects.
体外活性: IBR2可抑制三阴性人乳腺癌细胞株MBA-MD-468的生长,其半抑制浓度(IC50)为14.8 μM。IBR2展现出对RAD51的显著抑制活性,治疗后的癌细胞中RAD51快速降解,其同源重组修复功能受损,进而导致细胞死亡。IBR2对大多数测试的癌症细胞株的IC50值范围在12-20 μM之间[1]。
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 100 mg/mL (249.69 mM)
关键字: RAD51 | Apoptosis | IBR 2 | inhibit | Inhibitor | IBR2 | IBR-2
相关产品: Fosifloxuridine nafalbenamide | BCH001 | Rifabutin | 1-Hydroxyanthraquinone | Remdesivir | Valacyclovir hydrochloride | Setrobuvir | Shizukaol B | DNA Gyrase-IN-8 | Trovafloxacin mesylate
相关库: Anti-Cancer Compound Library | Bioactive Compounds Library Max | Human Metabolite Library | Inhibitor Library | Anti-Cancer Active Compound Library | DNA Damage & Repair Compound Library | Apoptosis Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途