化合物 T11613 T11613
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 2234285-81-3 | ¥16,100.00 | 询底价 |
100 mg | 2234285-81-3 | ¥27,500.00 | 询底价 |
50 mg | 2234285-81-3 | ¥21,300.00 | 询底价 |
Product Introduction
Bioactivity
英文名: IDH1 Inhibitor 1
描述: IDH1 Inhibitor 1 is an orally bioavailable, brain-penetrant, and selective mutant IDH1 inhibitor (IC50s: 0.021 μM, 0.045 μM, and 2.52 μM for IDH1R132H, IDH1R132C, and IDH1WT).
体外活性: IDH1 Inhibitor 1 inhibits cellular HCT116-IDH1R132H/+ with an IC50 of 0.039 μM.
体内活性: IDH1 Inhibitor 1 is also profiled in a patient-derived IDH1 mutant HCT116-IDH1R132H/+ mechanistic xenograft tumor model in mice to evaluate in vivo inhibition of 2-HG production. IDH1 Inhibitor 1, dosed orally at 150 mg/kg, inhibits new 2-HG production.IDH1 Inhibitor 1 ?inhibits 2-hydroxyglutarate (2-HG) production in a preclinical xenograft tumor model.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: IDH-1 Inhibitor 1 | IDH1 Inhibitor 1
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途