化合物IPR-803 T11666

Product Introduction
Bioactivity


英文名: IPR-803

描述: IPR-803 是一种有效的 uPAR·uPA 蛋白-蛋白相互作用抑制剂，具有抗肿瘤活性。 IPR-803 直接与 uPAR 结合，Ki 为 0.2 μM。

体外活性: IPR-803 (0-200 μM; 3 days) blocks the invasion of MDA-MB-231 cells, and most of the inhibition of cell invasion is unlikely due to the cytotoxicity of the compound. IPR-803 (50 μM; 30 minutes) shows inhibition of MAPK phosphorylation. IPR-803 blocks invasion of breast cancer cells line MDA-MB-231, and inhibits matrix metalloproteinase breakdown of the extracellular matrix. IPR-803 impairs MDA-MB-231 cell adhesion and migration. IPR-803 induces a concentration-dependent impairment of cell adhesion with an IC50 of 30 μM. IPR-803 inhibits MDA-MB-231 cells growth with an IC50 of 58 μM[1].

体内活性: In NSG mice with MDA-MB-231 cells xenograft, IPR-803 (200 mg/kg; i.g.; three times a week; for 5 weeks) impairs breast cancer metastasis with a t1/2 of 5 hours. IPR-803 has a low oral bioavailability at 4 percent, and remains high concentration even after 10 hours in tumor tissue[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 7 mg/mL (15.44 mM)


关键字: inhibit | IPR-803 | Inhibitor | Threonine proteases | Serine proteases | Ser/Thr Protease | IPR803 | Serine endopeptidases | IPR 803

相关产品: SM1-71 | PCSK9-IN-10 | SPHINX31 | CRT0066101 dihydrochloride | TAO Kinase inhibitor 2 | Camostat mesylate | ML-7 hydrochloride | R-IMPP | LP-935509 | FOY 251

相关库: Anti-Cancer Compound Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Inhibitor Library | Anti-Cancer Active Compound Library | PPI Inhibitor Library | Metabolism Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途