化合物 T11812L T11812L
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mL | 69955-42-6 | ¥1,420.00 | 询底价 |
100 mg | 69955-42-6 | ¥5,150.00 | 询底价 |
2 mg | 69955-42-6 | ¥663.00 | 询底价 |
Product Introduction
Bioactivity
英文名: L-Eflornithine monohydrochloride
描述: L-Eflornithine is an irreversible ornithine decarboxylase (ODC) inhibitor with a KD of 1.3±0.3 μM, and a Kinact of 0.15±0.03 min-1. L-Eflornithine monohydrochloride (L-DFMO monohydrochloride) is an enantiomer of Eflornithine.
体外活性: Treatment of human colon tumour-derived HCT116 cells with either L-Eflornithine or D- Eflornithine decreases the cellular polyamine contents in a concentration-dependent manner. The enantiomers display different potencies in vitro, with the L-enantiomer having up to a 20-fold higher affinity for the target enzyme ornithine decarboxylase. ?The L-Eflornithine also appears to be more potent in cultured T.brucei gambiense parasites.Eflornithine (D/L-DFMO) is an inhibitor of ODC, the first enzyme in eukaryotic polyamine biosynthesis.?Both enantiomers of Eflornithine (DFMO) irreversibly inactivate ODC.?Both Eflornithine enantiomers (L-Eflornithine and D-Eflornithine) suppress ODC activity in a time- and concentration-dependent manner.?The inhibitor dissociation constant (KD) values for the formation of enzyme-inhibitor complexes are 28.3±3.4, 1.3±0.3 and 2.2±0.4 μM respectively for D-Eflornithine, L-Eflornithine and Eflornithine.?The inhibitor inactivation constants (Kinact) for the irreversible step were 0.25±0.03, 0.15±0.03 and 0.15±0.03 min-1 respectively for D-Eflornithine, L-Eflornithine and Eflornithine.
体内活性: The typical oral clearances of L-Eflornithine and D-eflornithine are 17.4 and 8.23 liters/h, respectively.The more potent L-Eflornithine is present at much lower concentrations in both plasma and cerebrospinal fluid (CSF) than those of the D-Eflornithine.?The plasma concentrations of L-Eflornithine are on average 52% of the D-enantiomer concentrations.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: L-a-difluoromethylornithine Monohydrochloride | L-Eflornithine | L-RMI-71782 | L-RMI71782 Monohydrochloride | L-RMI 71782 | L-RMI-71782 Monohydrochloride | L-a-difluoromethylornithine | LEflornithine monohydrochloride | L-DFMO Monohydrochloride | L-RMI71782 | L-α-difluoromethylornithine Monohydrochloride | L-Eflornithine Monohydrochloride | L-RMI 71782 Monohydrochloride | L Eflornithine monohydrochloride | L-alpha-difluoromethylornithine Monohydrochloride | L-α-difluoromethylornithine | L-alpha-difluoromethylornithine | L-DFMO
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途