化合物LM11A-31 dihydrochloride T11861

Product Introduction
Bioactivity


英文名: LM11A-31 dihydrochloride

描述: LM11A-31 dihydrochloride 是一种具有高血脑屏障通透性的氨基酸衍生物，能阻断 p75 介导的细胞死亡。它是一种 p75NTR(神经营养蛋白受体 p75) 非肽调节剂，是口服有效的 proNGF 拮抗剂。它可以逆转中晚期的阿尔茨海默氏病小鼠模型中的胆碱能神经突营养不良。

体内活性: LM11A-31 (orally; 50 or 75 mg/kg) administered for 3 months starting at 6-8 months of age prevents and/or reverses atrophy of basal forebrain cholinergic neurites and cortical dystrophic neurites in mid-stage male APPL/S mice[2].?LM11A-31 (oral gavage;?50 mg kg/day for 4 weeks) significantly mitigates proNGF accumulation and preserves BRB integrity[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 125 mg/mL (395.23 mM)


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相关库: Drug Repurposing Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | CNS-Penetrant Compound Library | Inhibitor Library | Orally Active Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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