化合物MBM-55S T11961
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
10 mg | 2083624-07-9 | ¥4,390.00 | 询底价 |
5 mg | 2083624-07-9 | ¥2,990.00 | 询底价 |
25 mg | 2083624-07-9 | ¥6,910.00 | 询底价 |
100 mg | 2083624-07-9 | ¥12,800.00 | 询底价 |
1 mL | 2083624-07-9 | ¥4,280.00 | 询底价 |
50 mg | 2083624-07-9 | ¥9,490.00 | 询底价 |
1 mg | 2083624-07-9 | ¥1,290.00 | 询底价 |
2 mg | 2083624-07-9 | ¥1,930.00 | 询底价 |
500 mg | 2083624-07-9 | ¥25,600.00 | 询底价 |
Product Introduction
Bioactivity
英文名: MBM-55S
描述: MBM-55S 是一种有效的 Nek2 抑制剂,IC50 为 1 nM。 MBM-55S 抑制细胞周期停滞和凋亡,从而抑制癌细胞的增殖。 MBM-55S 表现出抗肿瘤作用。
体外活性: MBM-55S shows a 20-fold or greater selectivity in most kinases with the exception of RSK1 and DYRK1a with IC50s of 5.4 and 6.5 nM. MBM-55S inhibits MGC-803, HCT-116, and Bel-7402 the proliferation of cell with IC50s of 0.53, 0.84, and 7.13 μM, respectively. MBM-55S (0.5-1 μM) induces G2/M phase arrest and accumulation of cells with >4N content and causes cell apoptosis in a concentration-dependent manner in HCT-116 cells[1].
体内活性: In female BALB/c nu/nu mice, MBM-55S (20 mg/kg; i.p) exhibits good antitumor activity. In male Sprague Dawley rats, MBM-55S (1.0 mg/kg; i.v.) shows good pharmacokinetic profile with the CL, T1/2, Vss, AUC0-t, and AUC0-∞ values of 33.3 mL/min/kg, 1.72 hours, 2.53 L/kg, 495 ng/h/mL and 507 ng/h/mL, respectively[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 22.5 mg/mL (30.62 mM)
关键字: MBM 55S | MBM-55S | MBM55S
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相关库: Anti-Breast Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Cancer Compound Library | Anti-Lung Cancer Compound Library | Anti-Ovarian Cancer Compound Library | Inhibitor Library | Kinase Inhibitor Library | Cytoskeletal Signaling Pathway Compound Library | Anti-Cancer Active Compound Library | Tyrosine Kinase Inhibitor Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途