化合物Niraparib R-enantiomer T12064

Product Introduction
Bioactivity


英文名: Niraparib (R-enantiomer)

描述: Niraparib R-enantiomer (MK 4827 R-enantiomer) 是一种 PARP1抑制剂，IC50为 2.4 nM。

体外活性: Niraparib R-enantiomer has somewhat lower in vitro metabolic clearance than the Niraparib S-enantiomer in rat liver microsomes, but Niraparib S-enantiomer is more potent in cell based assays (PARylation EC50, Niraparib R-enantiomer=30 nM, Niraparib S-enantiomer=4.0 nM; BRCA1-HeLa CC50, Niraparib R-enantiomer=470, Niraparib S-enantiomer=34 nM). [1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 30 mg/mL (93.63 mM)


关键字: MK 4827 | MK-4827 | MK4827 | poly ADP ribose polymerase | Inhibitor | Niraparib (R enantiomer) | PARP | Niraparib (Renantiomer) | Niraparib (R-enantiomer) | Niraparib | inhibit

相关产品: Protodeltonin | Excisanin A | Myristicin | E7016 | Niraparib tosylate | JW 55 | PARP10-IN-3 | 1,5-Isoquinolinediol | PARP/PI3K-IN-1 | OUL232

相关库: Anti-Prostate Cancer Compound Library | Anti-Breast Cancer Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Anti-Ovarian Cancer Compound Library | Inhibitor Library | DNA Damage & Repair Compound Library | Anti-Pancreatic Cancer Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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