洛伐他汀 T1207

Product Introduction
Bioactivity


英文名: Lovastatin

描述: Lovastatin (MK-803) 是一种 HMG-CoA 还原酶抑制剂，用于降低胆固醇。

细胞实验: Hela cells are treated with lovastatin (0, 5, 10, 20, 40, 80, 160, 320 μg/mL) for 24 h. Cells treated with culture medium serves as a negative control. cell viability is measured using the MTT based colorimetric assay [2].

体内活性: Lovastatin 是一种在肝脏中水解为活性β-羟酸形式的不活跃乳酸内酯，其主要代谢产物是HMG-CoA还原酶的抑制剂（Ki：1nM）。Lovastatin 及其β-羟酸代谢产物高度结合于人类血浆蛋白。Lovastatin 能跨越血脑屏障和胎盘屏障[6]。Lovastatin 显著降低含有载脂蛋白B的脂蛋白颗粒，尤其是低密度脂蛋白胆固醇（LDL胆固醇），在较小程度上降低血浆甘油三酯，并略微提高高密度脂蛋白胆固醇水平[7]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 45 mg/mL (111.24 mM)
Ethanol : 20.2 mg/mL (50 mM))
5% DMSO+95% Saline : 2.03 mg/mL (5.01 mM, suspension)


关键字: MK 803 | Autophagy | Lovastatin | Inhibitor | Ferroptosis | MK803 | HMG-CoA Reductase (HMGCR) | inhibit

相关产品: Trigonelline | Acetylcysteine | L-Glutamic acid monosodium salt | SRS16-86 | Artemisinin | Linagliptin | Lepadin H | RSL3 | Sorafenib | Arteannuin B

相关库: Drug Repurposing Compound Library | Drug-induced Liver Injury (DILI) Compound Library | Anti-Cancer Drug Library | CNS-Penetrant Compound Library | Anti-Cancer Clinical Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | Natural Product Library for HTS | Microbial Natural Product Library | RO5 Drug-like Natural Product Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途