化合物 T12116 T12116

Product Introduction
Bioactivity


英文名: MSI-1436

描述: MSI-1436 is a selective, non-competitive the enzyme protein-tyrosine phosphatase 1B (PTB1B)inhibitor(IC50 of appr 1 μM)

体外活性: Trodusquemine significantly enhanced insulin-stimulated tyrosine phosphorylation of insulin receptor (IR) beta and STAT3, direct targets of PTP1B, in HepG2 cells in vitro and/or hypothalamic tissue[1].

体内活性: Trodusquemine (MSI-1436) causes rapid and reversible weight loss in genetic models of obesity.?Trodusquemine suppressed appetite, reduced body weight (BW) in a fat-specific manner, and improved plasma insulin and leptin levels in mice[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: MSI 1436 | MSI1436 | MSI-1436

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途