化合物 T12199L T12199L

Product Introduction
Bioactivity


英文名: NB-598 hydrochloride

描述: NB-598 hydrochloride is a competitive squalene epoxidase (SE) inhibitor.

体外活性: NB-598, an inhibitor of squalene epoxidase, on cholesterol absorption from the intestinal epithelia.?NB-598 (10 microM) inhibited the synthesis of sterol and sterol ester from [14C]acetate without affecting the synthesis of other lipids such as phospholipids (PL), free fatty acids (FFA) and triacylglycerol (TG).?When labeled lipid was apically loaded as a micellar lipid solution into Caco-2 cell cultures, NB-598 reduced basolaterally secreted radioactivity in cholesterol, cholesterol ester, PL and TG.?Furthermore, NB-598 suppressed the basolateral secretion of apolipoprotein (apo) B. When microsomes prepared from control Caco-2 cells were incubated with 10 microM NB-598, acyl CoA:cholesterol acyltransferase (ACAT) activity was inhibited slightly.?After incubating Caco-2 cells with 10 microM NB-598, a slight reduction in cellular ACAT activity was also observed.?These results suggest that suppression of the secretion of particles containing apo B and reduction of cellular ACAT activity in the intestinal epithelia are part of the mechanism of the cholesterol-lowering effect of NB-598.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: NB-598 Hydrochloride | NB598 hydrochloride | NB 598 Hydrochloride | NB598 Hydrochloride | NB 598 hydrochloride

相关产品: Ascomycin | Epothilone B | Camptothecin | Piperlonguminine | Quinoxyfen | 6'-O-beta-D-Glucosylgentiopicroside | nerolidol | Butenafine hydrochloride | Viridicatol | Toyocamycin

化合物 T12199L T12199L信息由TargetMol中国为您提供，如您想了解更多关于化合物 T12199L T12199L报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途