化合物 T12278 T12278

Product Introduction
Bioactivity


英文名: NXT629

描述: NXT629 is a selective and competitive antagonist of PPAR-α(human PPARα with an IC50 of 77 nM).

体外活性: NXT629 is a potent and selective antagonist of PPAR-α(human PPARα,IC50 of 77 nM), shows high selectivity over other nuclear hormone receptor, [2].

体内活性: NXT629 has poor oral bioavailability in mice and rats.?NXT629 (30 mg/kg, i.p., daily for 6 weeks) delays growth of subcutaneous SKOV-3 tumors in nude mice, inhibits growth of subcutaneous B16F10 tumors in C57Bl/6 mice.?NXT629 (30 mg/kg, i.p.) is weakly anti-angiogenic against FGF-induced angiogenesis.?NXT629 (3, 30 mg/kg, i.p.) inhibits experimental metastasis of B16F10 melanoma cells to the mouse lung[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 125 mg/mL (204.99 mM)


关键字: NXT 629 | NXT629 | NXT-629

相关产品: (-)-(S)-Equol | Endoxifen (Z-isomer) | (E/Z)-4-Hydroxytamoxifen | Mifepristone | DY131 | Etonogestrel | Iriflophenone | Isopsoralenoside | Ethynyl estradiol | Medroxyprogesterone

化合物 T12278 T12278信息由TargetMol中国为您提供，如您想了解更多关于化合物 T12278 T12278报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途