化合物 T12326 T12326
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
50 mg | 2260542-60-5 | ¥18,300.00 | 询底价 |
25 mg | 2260542-60-5 | ¥13,900.00 | 询底价 |
100 mg | 2260542-60-5 | ¥23,500.00 | 询底价 |
Product Introduction
Bioactivity
英文名: OSMI-2
描述: OSMI-2 is a cell-permeable inhibitor of O-linked N-acetylglucosamine transferase (OGT).
体外活性: In ?HCT116 cells,OSMI-2 ?treatment reduces O-GlcNAc levels at short treatment times (<8h).?However, O-GlcNAc levels begins to recover at longer treatment times with OSMI-2.?A decrease in HCF-1 cleavage products and the appearance of uncleaved HCF-1 in cells treated with OSMI-2 ?is observed.?Because OGT knockdown is known to decrease cell proliferation, the effects of OSMI-2 on cell growth in culture over 96h is also monitored.?Although there is no evidence of apoptosis, the reduced growth of cells over time is observed, consistent with the knockdown results.?A time course performed with 20 μM OSMI-2 shows reciprocal changes in the abundance of OGT and OGA, with a particularly large increase in OGT;?this may explain the recovery in O-GlcNAc levels with OSMI-2.?At 24h where O-GlcNAc levels fully recovered[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: OSMI2 | OSMI 2 | OSMI-2
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途