黄豆苷元 T1238

Product Introduction
Bioactivity


英文名: Daidzein

描述: Daidzein (Isoflavone) 是一种来自大豆的异黄酮提取物，是酪氨酸激酶抑制剂染料木黄酮的无活性类似物，具有抗氧化和植物雌激素特性。

细胞实验: Daidzein is dissolved in DMSO and then diluted with appropriate media[1]. HEK293T cells are plated on 24-well plates at a cell density of approximately 2.5×104 cells/well and are grown to 70-80% confluence. Cells are then transiently transfected with a PPAR-α or PPAR-γ expression plasmid, and a plasmid containing the luciferase gene under the control of three tandem PPAR response elements (PPRE × 3 TK-luciferase) using an X-treme GENE HP DNA Transfection Reagent. Renilla luciferase control vectors are co-transfected to control for transfection efficiency. After transfection, cells are cultured for another 24 h in medium containing DMSO or various concentrations (6.25, 12.5, 25 μM) of Daidzein. Cells are lysed, and luciferase activity is measured and expressed as fold induction, that is normalized to the activity of the renilla luciferase control plasmid[1].

体内活性: 大豆素导致雌性大鼠体重下降，这可能是由于饲料消耗减少所致。Daidzein 还会略微降低雌性大鼠的卵巢和子宫重量以及乳腺大小，但这种降低并不显著。[5]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 45 mg/mL (177 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)


关键字: PPAR | inhibit | Daidzein | Endogenous Metabolite | Inhibitor | Peroxisome proliferator-activated receptors

相关产品: NAD+ | Dopamine hydrochloride | UDP-rhamnose | Hippuric acid | Phosphorylcholine | Agmatine sulfate | 3-Hydroxyanthranilic acid | L-Gulono-1,4-lactone | 18β-Glycyrrhetinic acid | Cholic Acid

相关库: Drug Repurposing Compound Library | Tobacco Monomer Library | Anti-Cancer Drug Library | Selected Plant-Sourced Compound Library | Chinese Pharmacopoeia Natural Product Library | Inhibitor Library | Traditional Chinese Medicine Monomer Library | Anti-Cancer Approved Drug Library | Orally Active Compound Library | Gut Microbial Metabolite Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途