化合物 T12417 T12417

Product Introduction
Bioactivity


英文名: PF-04217903 methanesulfonate

描述: PF-04217903 methanesulfonate is a potent ATP-competitive inhibitor of c-Met kinase (Ki of 4.8 nM for human c-Met).

体外活性: PF-04217903 induces apoptosis of GTL-16 cells (IC50=31 nM) [1]. PF-04217903 methanesulfonate also inhibits HGF-mediated cell migration and Matrigel invasion in several c-Met–overexpressing tumor cell lines such as human NCI-H441 lung carcinoma and HT29 colon carcinoma with IC50 values comparable with those for inhibition of c-Met phosphorylation in these cell lines (IC50= 7-12.5 nM)[1].

体内活性: PF-04217903 methanesulfonate shows a significant dose-dependent reduction of human IL-8 levels in both the U87MG and GTL-16 models and decreases human VEGFA levels in the GTL-16 model. PF-04217903 methanesulfonate strongly induces phospho-PDGFRβ levels in U87MG xenograft tumors[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (106.73 mM)


关键字: PF-04217903 methanesulfonate | PF04217903 methanesulfonate | PF 04217903 methanesulfonate

相关产品: Altiratinib | AMG-337 | Glumetinib | Tivantinib | Ensartinib hydrochloride | c-Kit-IN-1 | SCR-1481B1 | Cabozantinib | Herbacetin | Norcantharidin

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途