化合物PF-06424439 methanesulfonate T12425

Product Introduction
Bioactivity


英文名: PF-06424439 methanesulfonate

描述: PF-06424439 methanesulfonate 是一种口服有效咪唑并吡啶二酰基甘油酰基转移酶 2 (DGAT2)选择性抑制剂，IC50是14 nM。PF-06424439 methanesulfonate 具有缓慢可逆，时间依赖性的特点，其相对于酰基-CoA 底物以非竞争性模式抑制 DGAT2。

动物实验: PF-06424439 methanesulfonate (i.v.; 1 mg/kg) shows moderate clearance in rats following intravenous administration and moderate steady-state volume of distribution (Vdss) results in a short half-life[1].PF-06424439 methanesulfonate (p.o.; 60 mg/kg/day; for 3 days) reduces plasma TG and cholesterol levels and decreases nonsignificant in circulating lipids in mice (Ldlr-/-)[1].

体内活性: PF-06424439 methanesulfonate shows moderate clearance in rats following intravenous administration and moderate steady-state volume of distribution (Vdss) results in a short half-life[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 249 mg/mL (464.50 mM)
H2O : 99 mg/mL (184.68 mM)


关键字: acyl-CoA:cholesterol acyltransferase | Inhibitor | Acyltransferase | mono- acylglycerol acyltransferase | PF-06424439 | PF 06424439 methanesulfonate | inhibit | Diacylglycerol acyltransferase | PF06424439 | Diglyceride acyltransferase | PF06424439 methanesulfonate | PF 06424439 | PF-06424439 methanesulfonate

相关产品: VULM 1457 | RHC 80267 | RP 70676 | Lateritin | BAY-3827 | Avasimibe | ACAT-IN-1 cis isomer | PF-07202954 | K-604 dihydrochloride | T863

相关库: Bioactive Compounds Library Max | Inhibitor Library | Anti-Obesity Compound Library | Lipid Metabolism Compound Library | Metabolism Compound Library | Orally Active Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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