醋酸甲羟孕酮 T1261

Product Introduction
Bioactivity


英文名: Medroxyprogesterone Acetate

描述: Medroxyprogesterone Acetate (Farlutin) 是广泛使用的合成类固醇，与雄激素，孕酮及糖皮质激素受体均有作用。

体外活性: MPA和黄体酮显著减少海马中GAD水平,MPA和黄体酮明显增加内嗅皮质的GAD水平.MPA在老年卵巢切除大鼠中,损害水面上旋臂迷宫延迟记忆保留,并加剧Morris水迷宫的隔夜遗忘.

体内活性: Medroxyprogesterone acetate（MPA）减少人乳腺癌细胞中IL-6和PTHrP的分泌。MPA在KTC-2细胞中,以剂量依赖的方式减少IL-6和PTHrP的分泌和表达。MPA和地塞米松在M-1细胞中,剂量依赖性增加α-ENaC的启动子驱动的萤光素酶活性,这不受Org31710抑制,这表明MPA调节的α-ENaC与PR无关。MPA和地塞米松在M-1和Madin-Darby狗肾-C7细胞中,剂量依赖性增加α-ENaC的和SGK1的mRNA,但黄体酮无此作用。0.1 nM MPA明显增强体外特异性免疫球蛋白G抗体的产生,该作用似乎涉及孕激素与PRG受体的相互作用。MPA抑制3- hydroxyste-固醇脱氢酶,参与THP和DHP之间的可逆转换,因此,可能会影响到大脑中DHP和THP的作用。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 10 mg/mL (25.9 mM)
Ethanol : 10 mg/mL (25.9 mM)


关键字: Medroxyprogesterone Acetate | Inhibitor | Androgen Receptor | Endogenous Metabolite | Glucocorticoid Receptor | NSC26386 | Medroxyprogesterone | Progesterone Receptor | NR3C3 | inhibit | NSC 26386

相关产品: Amcinonide | Glucocorticoid receptor agonist-1 | Spironolactone | Desonide | Corticosterone | Fluorometholone | Canrenoate potassium | Methylprednisolone succinate | HP210 | Dicirenone

相关库: PBCRBS Traditional Chinese Medicine Compound Library | Drug Repurposing Compound Library | Approved Drug Library | Anti-Cancer Drug Library | Selected Plant-Sourced Compound Library | Anti-Cancer Clinical Compound Library | Nuclear Receptor Compound Library | Anti-Cancer Approved Drug Library | Traditional Chinese Medicine Monomer Library | Anti-COVID-19 Traditional Chinese Medicine Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途