(R)(−)-α-甲基组胺 二盐酸盐 T12630

Product Introduction
Bioactivity


英文名: (R)-(-)-α-Methylhistamine dihydrobromide

描述: (R)-(-)-α-Methylhistamine dihydrobromide is a potent and selective agonist of H3 histamine receptor( Kd of 50.3 nM).

体外活性: (R)-(-)-α-Methylhistamine dihydrobromide is an H3-agonist that is > 10 times as potent as histamine (HA).(R)-(-)-α-Methylhistamine dihydrobromide has only weak affinities for H1 and H2 receptor with a pKi=4.8 and < 3.5, repectively. Its selectivity toward H3-receptors is > 1,000 times as high as that of HA. (R)-(-)-α-Methylhistamine dihydrobromide displays >200-fold selectivity over H4 receptors[1].

体内活性: (R)-alpha-Methylhistamine dihydrochloride (6.3 mg/kg; i.p.) significantly decreases the steady-state t-MH level in the mouse brain, whereas these compounds produced no significant changes in the HA level[2].Pretreatment with (R)-(-)-α-Methylhistamine dihydrobromide reverses propofol‐induced memory retention[4].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: a-Methylhistamine Dihydrobromide | alpha-Methylhistamine Dihydrobromide | (R)()αMethylhistamine dihydrobromide | a-Methylhistamine | α-Methylhistamine Dihydrobromide | α-Methylhistamine | alpha-Methylhistamine | (R) ( ) α Methylhistamine dihydrobromide

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