化合物 T12722 T12722
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 2309762-18-1 | ¥10,600.00 | 询底价 |
100 mg | 2309762-18-1 | ¥17,500.00 | 询底价 |
50 mg | 2309762-18-1 | ¥13,800.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Ribocil-C Racemate
描述: Ribocil-C Racemate 是 Ribocil-C 的外消旋体。Ribocil-C 是具有高度选择性的,细菌核黄素核糖开关 (bacterial riboflavin riboswitches) 抑制剂。
体外活性: Ribocil-C is a highly selective inhibitor of the flavin mononucleotide (FMN) riboswitch. Ribocil-C controls expression of de novo riboflavin (RF, vitamin B2) biosynthesis in Escherichia coli. Ribocil-C specifically inhibits dual FMN riboswitches, separately controlling RF biosynthesis and uptake processes essential for Staphylococcus aureus growth and pathogenesis [1]. Ribocil-C is a small-molecule synthetic mimic of FMN that binds the FMN riboswitch of multiple GN bacteria, including Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii, to inhibit ribB expression, RF synthesis, and consequently arrest bacterial growth [1] [2].
体内活性: Higher dose Ribocil-C treatment groups (60 and 120 mg kg21 ribocil-C) show a dose-dependent reduction in bacterial burden of 1.87 and 3.29 log 10 [CFU per g spleen] reduction respectively versus shamtreated mice, without mortality or gross effects of toxicity observed [2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 30 mg/mL (71.51 mM)
关键字: Ribocil-C Racemate | Ribocil C Racemate | RibocilC Racemate
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途