(S)-卡维地洛 T12794
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
100 mg | 95094-00-1 | ¥17,500.00 | 询底价 |
50 mg | 95094-00-1 | ¥13,800.00 | 询底价 |
25 mg | 95094-00-1 | ¥10,600.00 | 询底价 |
Product Introduction
Bioactivity
英文名: (S)-Carvedilol
描述: (S)-Carvedilol is a non-selective β/α-1 blocker.It exerts protection against the vascular or cardiac toxicity of Doxorubicin (DOX).
体外活性: (S)-Carvedilol is about 100 times greater than that of (R)-Carvedilol in β-receptor blocking activity, whereas both enantiomers show equipotent potency as α-blockers. (S)-Carvedilol treatment significantly upregulates the expression levels of p-eNOS in HUVECs. (S)-Carvedilol significantly attenuates Doxorubicin (DOX)-induced cell death, apoptotic morphological changes, decrease the mitochondrial membrane potential and oxidative stress responses by increasing the superoxide dismutase and catalase activities, and decreasing malondialdehyde contents and reactive oxygen species levels via the PI3K/AKT/eNO synthase pathway in vitro.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: BM-14190 | Carvedilol | BM 14190 | (S)Carvedilol | (S) Carvedilol | BM14190
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途