化合物 T12888 T12888

Product Introduction
Bioactivity


英文名: MGV354

描述: MGV354 是一种可溶性鸟苷酸环化酶 (sGC) 激活剂，在 CHO 和 GTM-3E 细胞中 EC50值分别为 <0.5 nM 和 5 nM。

体外活性: MGV354 (0.1 nM-10 μM) treatment for 1 hour causes a dose-dependent increase in cGMP levels in normal human trabecular meshwork (NTM) cells (average EC 50 =2.5±1.6 nM) following treatment with ODQ (20 μM). The average cGMP produced by MGV354 in human NTM cells is 46±28 nM. MGV354 (1 μM) leads to a linear increase in intracellular cGMP levels in NTM cells in a time-dependent manner (assay conditions up to 3 hours) [3].

体内活性: MGV354 (Compound (+)-23) robustly lowers intraocular pressure in a cynomolgus model of elevated intraocular pressure over 24 h after a single topical ocular drop and has been selected for clinical evaluation [1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: MGV 354 | MGV354 | MGV-354

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途