夫西地酸钠 T1289

Product Introduction
Bioactivity


英文名: Fusidic acid sodium salt

描述: Fusidic acid sodium salt (SQ-16360) 是一种Fusidium coccineum 属甾体类抑菌抗生素。它阻止核糖体释放翻译延长因子G 来抑制细菌生长。

激酶实验: Binding assays: Binding assays are performed as previously described (Allenby et al., 1993, 1994). Briefly, labeled and unlabeled retinoids are added to nucleosol or cytosolic fractions in ethanol so that the total amount of ethanol added is constant in all tubes and did not exceed 2% of the incubation volume. The receptor preparations are incubated with retinoids at 4°C for 4–6 hr. Sephadex PD-10 desalting columns are used to separate bound radioligand from free radioligand after equilib- rium is achieved. For competitive binding assays, varying concentrations of unlabeled competing ligand are incubated with the appropriate nucleosol or cytosol in the presence of a fixed concentration of [3H]tRA (sp. act. 49.3 Ci/mmol) or [3H]9-cis RA (sp. act. 24.0 Ci/mmol). Final concentrations of [3H] tRA and [3H]9-cis RA for nuclear receptor binding assays are 5 nM. Final concentrations of [3H] tRA for CRABP binding assays is 30 nM. The IC50s are calculated as described above (DeLean et al., 1978). For saturation kinetics, increasing concentrations of radiolabeled ligand ([3H]tRA sp. act. 49.3 Ci/mmol, [3H]TTNPB sp. act. 5.5 Ci/ mmol) are added to the nucleosol of the appropriate receptor subtype in the presence (nonspecific binding) or absence (total binding) of a 100-fold molar excess of the corresponding unlabeled retinoid. Specific binding is defined as the total binding minus nonspecific binding. Saturation kinetics are calculated as previously described (Scatchard, 1949; Grippo and Gudas, 1987; Levin et al., 1992).

体内活性: Fusidin（Fusidate Sodium）至少在一定程度上通过抑制TNF-α的分泌改善EAM[1]。Fusidin显著减轻了给予链脲佐菌素（SZ）的小鼠免疫炎症糖尿病的临床和组织学征象。该作用是剂量依赖性的，且在三个不同的小鼠品系中均有观察到。因此，Fusidin 可能具有抗糖尿病效应[2]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : 93 mg/mL (172.6 mM)
H2O : 92 mg/mL (170.8 mM)
DMSO : 93 mg/mL (172.6 mM)


关键字: bacteriostatic | ribosome | Fusidic acid | Bacterial | factor | Inhibitor | SQ 16360 | Fusidic acid sodium salt | Antibiotic | growth | elongation | inhibit | steroids | SQ16360 | Fusidic acid sodium

相关产品: Fusidic acid | Isoniazid | 2-Pyridinecarbohydrazide | Fomepizole | Ethionamide | Chlorhexidine diacetate | Chlorhexidine | Chlorhexidine dihydrochloride

相关库: Anti-Aging Compound Library | Drug Repurposing Compound Library | Antibiotics Library | Oxidation-Reduction Compound Library | Clinical Compound Library | Inhibitor Library | Natural Product Library for HTS | Anti-Bacterial Compound Library | Microbial Natural Product Library | Anti-Infection Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途