盐霉素 A T12917
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
500 μg | 12656-09-6 | ¥6,930.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Siomycin A
描述: Siomycin A is a thiopeptide antibiotic and is a selective inhibitor of Forkhead box M1(FOXM1) without affecting other members of the Forkhead box family, has anti-tumor and promotes apoptosis.
体外活性: cell viability in a dose-dependent and a time-dependent association in K562, MCF7 and MiaPaCa-2 cells markedly reduced by Siomycin A (0-10 μM; 24-72 hours; K562, MCF7 and MiaPaCa-2 cells). Among the three cell lines(IC50 of the human leukemia K562 cells is the lowest at 6.25 μM at 24 h), while that for the human pancreatic cancer MiaPaCa-2 cells is 6.38 μM. However, the IC50 of the human pancreatic cancer MiaPaCa-2 cells at 48 and 72 h are the lowest of the three cell lines, which are 0.76 and 0.54 μM, respectively[1]. Siomycin A (0-10 μM; MiaPaCa-2 cells) treatment has potent proapoptotic effect in MiaPaCa-2 cells[1]. Siomycin A (0-10 μM; 24 hours; MiaPaCa-2 cells) treatment significantly reduces the expression levels of MMP-2, MMP-9 and α-tubulin protein in the MiaPaCa-2 cells[1].
体内活性: In vivo mouse model,Siomycin A (1 μM; subcutaneous injection; for 4 weeks; male Balb/c nude mice) pretreatment decreases tumour growth [2].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: Siomycin A
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途