加替沙星 T1293

Product Introduction
Bioactivity


英文名: Gatifloxacin

描述: Gatifloxacin (CG5501) 是一种具有广谱抗菌活性的氟喹诺酮类抗生素。它可抑制大肠杆菌 DNA 解旋酶 (IC50=0.109 μg/ml) 和细菌 II 型拓扑异构酶(IC50=13.8 μg/ml)。在动物模型中，它有抗细菌性结膜炎作用。

体外活性: Gatifloxacin提高正常和糖尿病大鼠中血清肾上腺素浓度.Gatifloxacin减小正常和糖尿病大鼠的血清葡萄糖浓度.

体内活性: Gatifloxacin针对细菌II型拓扑异构酶显示有效的抑制活性,对金黄色葡萄球菌拓扑异构酶和肠杆菌DNA促旋酶的IC 50分别为13.8 mg/mL和0.109 mg/mL,对HeLa细胞拓扑异构酶II 的活性最低,IC 50 =265 mg/mL。Gatifloxacin抑制M. tuberculosis ATCC 35801,MIC为0.125 μg/mL。Gatifloxacin和Ciprofloxacinplus联用表现对19％的31种绿脓杆菌的协同作用。Gatifloxacin的活性低于ciprofloxacin的2倍,活性比ofloxacin对Enterobacteriaceae低2倍。Gatifloxacin对流感嗜血杆菌,军团菌,幽门螺杆菌有很强的抗菌活性（MIC90s,0.03-0.06 mg/L）,有至少8倍的抗衣原体和抗支原体效力（加替沙星MIC90s,0.13 mg/L）。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 3.8 mg/mL (10 mM)


关键字: Inhibitor | S. aureus | E. coli,?Pseudomonas aeruginosa,?Micrococcus luteus | Gatifloxacin | Topoisomerase | hyperglycemia | N. brasiliensis | conjunctivitis | AM1155 | Antibiotic | CG-5501 | Bacterial | PD-135432 | BMS206584 | inhibit | diabetic | hypoglycemia | AM 1155 | PD135432 | actinomycetoma | BMS 206584 | CG 5501

相关产品: Doxorubicin | Nalidixic acid sodium salt | LMP744 hydrochloride | Daniquidone | Zoliflodacin | Proscillaridin A | TAK1 inhibitor | Etoposide | Pefloxacin Mesylate | Enoxacin

相关库: Drug Repurposing Compound Library | FDA-Approved & Pharmacopeia Drug Library | Bioactive Compounds Library Max | Human Metabolite Library | Inhibitor Library | DNA Damage & Repair Compound Library | Anti-Bacterial Compound Library | Target-Focused Phenotypic Screening Library | Nonsteroidal Anti-Inflammatory Compound Library | NO PAINS Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途