化合物SM-276001 T12933

Product Introduction
Bioactivity


英文名: SM-276001

描述: SM-276001 是可口服的干扰素诱导剂，是选择性TLR7激动剂，可以诱导抗肿瘤免疫反应。

体外活性: SM-276001（1 nM-10 μM）通过人类TLR7 [2] 剂量依赖性激活NF-κB。

体内活性: 对小鼠进行口服给药 0.1mg/kg，SM-276001显示出强大的干扰素诱导活性[1]。对小鼠进行每周两次的3mg/kg口服给药，SM-276001显著减轻负担着Renca或CT26肿瘤的小鼠疾病负荷[2]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 100 mg/mL (305.46 mM)


关键字: immune | IFNAR | Interferon-alpha/beta receptor | IFN | Toll-like Receptor (TLR) | inhibit | TLR7 | Inhibitor | Interferon-α/β receptor | interferon | SM-276001 | SM 276001 | antitumor | SM276001

相关产品: Isofraxidin | Hydroxychloroquine | TLR7/8-IN-1 | TLR7/8 agonist 3 | CU-T12-9 | M62812 | Loxoribine | Pam3CSK4 TFA (112208-00-1 free base) | Afimetoran | TLR4-IN-C34

相关库: Anti-Aging Compound Library | Pyroptosis Compound Library | Cytokine Inhibitor Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Anti-Cancer Active Compound Library | Reprogramming Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途