化合物 T12978 T12978

Product Introduction
Bioactivity


英文名: NSC-70220

描述: SOS1-IN-1 is an inhibitor of SOS1.

体外活性: SOS1-IN-1 (40 μM) and NSC-658497(30 μM) result in growth inhibitory rate of 29% and 8% respectively. The combination treatment results in growth inhibitory rate of 54%, showing the synergistic effect of SOS1-IN-1 and NSC-658497 on cell growth inhibition. It is showed that the treatment with NSC-658497 at 40 μM for 2 hours alone or in combìnation with the treatment with 40 μM of SOS1-IN-1 overnight resulted in lower expression levels of P-AKT and P-ERK. The treatment wlth 40 μM of SOS1-IN-1 overnight resulted in lower expression levels of P-ERK.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 12.5 mg/mL (38.42 mM)


关键字: NSC-70220 | NSC 70220 | NSC70220

相关产品: Rineterkib | AD80 | PLX-4720 | Regorafenib monohydrate | Locostatin | Dabrafenib Mesylate | AZ304 | BMS-214662 | TBAP-001 | MRTX0902

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途