化合物ST1936 oxalate T13007

Product Introduction
Bioactivity


英文名: ST1936 oxalate

描述: ST1936 oxalate 是一种 5-HT6 受体的选择性纳摩尔亲和激动剂，对人5-HT6、5-HT7和 5-HT2B 受体的 Ki 值分别为 13、168 和 245 nM。

体外活性: ST1936 appears to be relatively selective for the 5-HT6 receptors, although it has shown affinity also for 5-HT2B, 5-HT1A, 5-HT7 receptor and α-adrenergic receptors when tested in a broad crossreactivity panel that comprised G-protein-coupled receptors, ion channel binding sites, enzymes, and transporters.

体内活性: Extracellular single-unit recordings are performed from putative dopamine-containing neurons in the SNc and VTA of anesthetised rats (Male Sprague-Dawley rats).In the VTA, ST1936 induces either dose-related increases (45% of cells) or decreases in basal activity of these dopaminergic neurons.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: phosphorylation | Beta Receptor | 5-HT6 receptor subtype | Adrenergic Receptor | ST-1936 | ST1936 | ST1936 oxalate | prefrontal cortex | ST-1936 Oxalate | Inhibitor | ST 1936 | 5-hydroxytryptamine Receptor | 5-HT Receptor | ST-1936 oxalate | ST 1936 Oxalate | ST1936 Oxalate | Fyn | Serotonin Receptor | inhibit | neurons

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