化合物SU3327 T13018

Product Introduction
Bioactivity


英文名: SU3327

描述: SU3327 (halicin) 是具有底物竞争性的 JNK 选择性抑制剂，IC50为 0.7 μM。它还抑制 JNK 和 JIP 之间的蛋白相互作用，IC50值为 239 nM。

体外活性: TNF-α stimulated phosphorylation of c-Jun in HeLa cells inhibited by SU3327 with EC50 of 6.23 μM[1]. SU3327 (25 nM) pretreatment of human-derived cerebral microvascular endothelial cells (hCMEC/D3) effectively reduces LPS-induced polymorphonuclear leukocytes (PMN) rolling/adhesion to hCMEC/D3, prevents activation of AP-1, and significantly reduces expression of VCAM-1[3].

体内活性: In male BKS.Cg-+Leprdb/+Leprdb/OlaHsd db/db mice, SU3327 (25 mg/kg; intraperitoneal injection; ) treatment possesses the ability to restore insulin sensitivity in mice models of diabetes[1]. SU3327 has favorable microsomal and plasma stability (T1/2 = 27 min)[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 62.5 mg/mL (239.19 mM)


关键字: JNK | Thiadiazole | TNF-α | Inhibitor | SU 3327 | inhibit | p38α | insulin | phosphorylation | substrate-competitive | SU-3327 | JIP | SU3327 | protein-protein | PPI

相关产品: Isopedicin | JNK-IN-7 | TOMATIDINE HYDROCHLORIDE | Tanzisertib | Nepetoidin B | Tomatidine | Uvaol | TAK-715 | Vacquinol-1 | Grasshopper ketone

相关库: Anti-Neurodegenerative Disease Compound Library | Pyroptosis Compound Library | Anti-Ovarian Cancer Compound Library | Kinase Inhibitor Library | Inhibitor Library | Anti-Diabetic Compound Library | Anti-Obesity Compound Library | Anti-Colorectal Cancer Compound Library | PPI Inhibitor Library | MAPK Inhibitor Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途