化合物 T13093 T13093

Product Introduction
Bioactivity


英文名: Tauro-β-muricholic acid sodium

描述: Tauro-β-muricholic Acid sodium is a endogenous metabolite, is a competitive and reversible antagonist of farnesoid X receptor (FXR)(IC50 of 40 μM).

体外活性: In the CRC cell line HT29, T-βMCA sodium inhibits FXR reporter activity (EC50 ~10 μM)[3].In HT29 and HCT116 cells, T-βMCA sodium dose-dependently increases WNT signaling [3]. T-βMCA sodium induces proliferation and DNA damage in Lgr5+ cells[3].

体内活性: T-βMCA sodium treatment also significantly increases levels of serum cytokines, including IFN-γ, IL-6, and IL-17[3].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: T-betaMCA sodium | Tauro-b-muricholic acid sodium | T-bMCA sodium | Tauroβmuricholic acid sodium | Tauro β muricholic acid sodium | Tauro-β-muricholic acid sodium | Tauro-beta-muricholic acid sodium

相关产品: Vonafexor | DY268 | Glyco-Obeticholic acid | GSK2324 | INT-767 | Turofexorate Isopropyl | Obeticholic Acid | Osocimab | Tauro-β-muricholic acid | Lithocholic acid

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途