化合物 T13144 T13144

Product Introduction
Bioactivity


英文名: Thiazinamium chloride

描述: Thiazinamium chloride possesses potent anticholinergic and antiallergic activity and inhibits synthesis of TxB2(IC50 value of 0.2 μM).

体外活性: thiazinamium chloride and promethazine inhibits TxB2 synthesis by resting macrophages in a dose-dependent manner. Thiazinamium chloride inhibits TxBz synthesis but had no effect on the ingestion of zymosan particles. In contrast, chlorpromazine inhibits phagocytosis but not TxBz synthesis except at lo-3 M. Under the condition where indomethacin, a nown cyclooxygenase inhibitor, is inhibitory, promethazine but not thiazinamium chloride inhibits TxB2 synthesis from exogenous arachidonic acid. Treatment of macrophages with promethazine and chlorpromazine but not thiazinamium chloride results in a reduction in the oxidative burst during phagocytosis. Furthermore, the ability of thiazinamium chloride to selectively inhibit arachidonic acid metabolism may contribute to its bronchodilator/antiallergic activity.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Thiazinamium chloride | Multergan Chloride | Thiazinamium Chloride

化合物 T13144 T13144信息由TargetMol中国为您提供，如您想了解更多关于化合物 T13144 T13144报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途