替鲁膦酸钠 T13159

Product Introduction
Bioactivity


英文名: Tiludronate disodium

描述: Tiludronate disodium (Tiludronic acid disodium) 是一种破骨细胞液泡 H(+)-ATPase 抑制剂，具有抗骨吸收和抗炎特性。 Tiludronate disodium 可用于有关代谢性骨病的研究。

体外活性: Tiludronate displays potent inhibitory against proton transport in yeast microsomal preparations with an IC50 of 3.5 μM and inhibits the activity of purified yeast V-ATPase. Tiludronate inhibits proton transport with IC50s of 1.1 mM and 466 nM in kidney-derived vesicles and vesicles derived from osteoclasts[3].

体内活性: Tiludronate dose-dependently inhibits the resorption of bones. Tiludronate reduces the secrete proton of mature osteoclasts into the resorption space and favors the detachment of mature osteoclasts from the bone matrix. Oral administration of Tiludronate (5-200 mg/kg) prevents the decrease in the skeletal mass in the castrated male rat model[3].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 56.2 mg/mL (155.1 mM)


关键字: Tiludronate disodium | Tiludronate | Tiludronic acid

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相关库: FDA-Approved Drug Library | Drug Repurposing Compound Library | Approved Drug Library | Mitochondria-Targeted Compound Library | FDA-Approved & Pharmacopeia Drug Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途