化合物UNC10217938A盐酸盐 T13254L

Product Introduction
Bioactivity


英文名: UNC10217938A HCl

描述: UNC10217938A HCl (UNC7938 HCl) 是具有寡核苷酸 (oligonucleotides) 增强作用的 3-deazapteridine 类似物， 通过调节寡核苷酸在细胞内的运输和从内体中的释放来增强寡核苷酸的作用。UNC10217938A HCl 还增强了 siRN 和反义寡核苷酸的作用。

体外活性: UNC10217938A HCl strongly enhances luciferase induction in HelaLuc705 cells when used in the 5-25 µM range and are substantially more effective and potent than Retro-1. As compared to splice switching oligonucleotide (SSO) alone, UNC10217938A HCl provids a 60-fold enhancement at 10 µM and 220-fold at 20 µM, in contrast to a 11-fold enhancement for 100 µM Retro-1[1]. UNC10217938A HCl can substantially enhance effects of receptor targeted oligonucleotide conjugates. UNC10217938A HCl also can enhance effects of uncharged morpholino oligonucleotides as well as negatively charged oligonucleotides[1]. Exposure of cells to UNC10217938A HCl leads to a major reduction in co-localization of the TAMRA-oliogonucleotide with the late endosome marker Rab7, but had little effect on co-localization with the lysosomal marker LAMP-1. UNC10217938A HCl causes partial release of oligonucleotide from late endosomes to the cytosol followed by nuclear accumulation[1].

体内活性: Systemic treatment with SSO623 followed by administration of UNC10217938A HCl (7.5 mg/kg; intravenous injection) produces distinct increases in EGFP fluorescence in liver, kidney and heart in EGFP654 mice[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (101.41 mM）


关键字: UNC10217938A HCl(1347749-97-6 Free base) | UNC10217938A HCl

相关库: Bioactive Compounds Library Max | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途