α-羟基油酸 T13430

Product Introduction
Bioactivity


英文名: ABTL-0812

描述: ABTL-0812 induces endoplasmic reticulum (ER) stress-mediated autophagy, and with anti-cancer activity.

体外活性: cell viability of squamous NSCLC H157 cells inhibited by ABTL-0812 (ABTL0812; 10-100 μM; 48 hours). Compared with squamous NSCLC H157 cells, human lung fibroblast cell line MRC-5 are resistant to ABTL0812 treatment.

体内活性: In human lung and pancreatic xenografts, ABTL-0812 (ABTL0812; 120 mg/kg; oral gavage; 5 times per week; for 33 d) induces ER stress. In vivo, ABTL-0812 induces hallmarks of ER stress . ABTL-0812 increases ATF4 and HSPA5 expression in mice bearing MiaPaca2 and A549 xenograft, respectively.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: ABTL-0812 | alpha-Hydroxylinoleic acid | ABTL 0812 | ABTL0812 | a-Hydroxylinoleic acid

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途