3-氧代-5β-胆烷酸 T13502
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 1553-56-6 | ¥650.00 | 询底价 |
10 mg | 1553-56-6 | ¥417.00 | 询底价 |
1 mL | 1553-56-6 | ¥460.00 | 询底价 |
5 mg | 1553-56-6 | ¥255.00 | 询底价 |
100 mg | 1553-56-6 | ¥1,347.00 | 询底价 |
50 mg | 1553-56-6 | ¥925.00 | 询底价 |
Product Introduction
Bioactivity
英文名: 3-Oxo-5β-cholanoic acid
描述: 3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) 是胆汁酸的一种代谢产物。3-Oxo-5β-cholanoic acid 直接与关键转录因子RORγt(Kd=1.13 μM) 结合抑制TH17细胞分化。
体外活性: 处理3-Oxo-5β-cholanoic acid显著降低了RORγt报告基因的活性。3-Oxo-5β-cholanoic acid很可能通过与RORγt的物理相互作用来抑制TH17细胞的分化,并且抑制其转录活性。
体内活性: 3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (0.3% (w/w); p.o.; for 1 week) significantly reduces the percentage of ileal TH17 cells[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 65 mg/ml (173.54 mM)
关键字: cell | factor | RAR-related orphan receptor | 3 Oxo 5β cholanoic acid | TH17 | RORγt | 3-Oxo-5b-cholanoic acid | differentiation | acid | bile | Inhibitor | responses | transcription | inhibit | ROR | 3-Oxo-5β-cholanoic acid | 3-Oxo-5beta-cholanoic acid | 3Oxo5βcholanoic acid | immune | 3-oxoLCA
相关产品: RORγt inverse agonist 14 | XY101 | RORγt Inverse agonist 8 | Cintirorgon | Methyl-3β-hydroxycholenate | Nobiletin | SR3335 | A-9758 | GSK805 | Cabozantinib hydrochloride
相关库: Transcription Factor-Targeted Compound Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Nuclear Receptor Compound Library | Natural Product Library for HTS | Metabolism Compound Library | Natural Product Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途