化合物 T13627 T13627

Product Introduction
Bioactivity


英文名: CP-10

描述: CP-10 is a PROTAC with highly selective and remarkable CDK6 degradation (DC50: 2.1 nM). It inhibits the proliferation of several hematopoietic cancer cells including multiple myeloma and can degrade mutated and overexpressed CDK6.

体外活性: In human glioblastoma U251 cells, CP-10 induces nearly 72% degradation of CDK6 at 10 nM and 89% at 100 nM. The degradation of CDK4 induced by CP-10 is far weaker than that of CDK6 (DC50: 50-80 fold). CP-10 displays a cell inhibition potential in mantle cell lymphoma cells (in Mino, IC50≈8 nM) and multiple myeloma cell MM.1S (IC50≈10 nM).

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 200 mg/mL (229.37 mM)


关键字: CP-10 | CP10 | CP 10

相关产品: PF-562271 hydrochloride | AS2863619 | GW297361 | (±)-Enitociclib | (S)-Enitociclib | 5-Iodo-indirubin-3'-monoxime | Furanodiene | Ergosterol peroxide | Trilaciclib | CDK8/19-IN-1

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途