灰黄霉素 T1382
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
500 mg | 126-07-8 | ¥333.00 | 询底价 |
1 mL | 126-07-8 | ¥418.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Griseofulvin
描述: Griseofulvin (Fulvicin) 是一种螺环真菌天然抗菌药,用于治疗真菌性皮肤癣菌。
细胞实验: The cells (5× 103/mL) are incubated in triplicate in a 96-well plate in the presence or absence of indicated concentration of Griseofulvin in a final volume of 0.2 mL for different time intervals at 37 ℃. Thereafter, 20 μL MTT solution (5 mg/mL in PBS) is added to each well. After a 2-hour incubation at 37 ℃, 0.1 mL lysis buffer (20% SDS, 50% dimethylformamide) is added, incubation is continued overnight at 37 ℃, and then the optical density at 570 nm is measured by plate reader. (Only for Reference)
体外活性: Griseofulvin在体内具有有效的抗感染活性.Griseofulvin和nocodazole (5 毫克/千克)一起治疗显著增强nocodazole的功效,导致肿瘤生长停止.
体内活性: 体外测试的Griseofulvin对各种皮肤癣菌的最小抑菌浓度范围为0.14到0.6 μg/mL。Griseofulvin对细胞有丝分裂的主要作用是纺锤体微管的解体。Griseofulvin也能够诱导哺乳动物细胞中染色体结构畸变。Griseofulvin能够有效抵抗小孢子菌属,毛癣菌属和表皮癣菌属等不同种类的皮肤癣菌。对其它的真菌,比如短帚霉和亨德逊酵母样菌是不敏感的。Griseofulvin对酵母菌几乎没有影响。
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 47 mg/mL (133.2 mM)
Ethanol : < 1 mg/mL (insoluble or slightly soluble)
H2O : < 1 mg/mL (insoluble or slightly soluble)
关键字: Apoptosis | Antibiotic | Fungal | Inhibitor | inhibit | Griseofulvin
相关产品: Ceramide (Egg, Chicken) | Dapivirine | XST-14 | Acacetin | BTT-3033 | Flurochloridone | Ursonic Acid | INH6 | Ubiquitin Isopeptidase Inhibitor I, G5 | alpha-Mangostin
相关库: Drug Repurposing Compound Library | Microtubule-Targeted Compound Library | Anti-Cancer Drug Library | Clinical Compound Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Approved Drug Library | Natural Product Library for HTS | Microbial Natural Product Library | RO5 Drug-like Natural Product Library | Covalent Inhibitor Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途