化合物 T13929 T13929
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
5 mg | 2229037-19-6 | ¥7,570.00 | 询底价 |
Product Introduction
Bioactivity
英文名: TL13-112
描述: TL13-112 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.14 nM).
体外活性: TL13-112 binds to cereblon(IC50 of 2.4 uM). in H3122 cell and Karpas 299, TL13-112 (0.01 μM-1 μM; 16 hours)?is selective for degradation of ALK(DC50s of 10 nM and 40 nM, respectively). ALK degradation acts at 4 hours of treatment in H3122 cells and at 8 hours of treatment in Karpas 299 cells. The maximum degradation achieves at 16 hours in both cell lines. .TL13-112 (0.01 μM-1 μM; 16 hours) inhibits PTK2, ALK, FER, RPS6KA1 and Aurora A expression as a dose-dependent manner in H3122, Karpas 299, and Kelly cells.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: TL13-112 | TL13 112 | TL-13-112 | TL13112
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途