花生四烯酸乙醇胺 T14046

Product Introduction
Bioactivity


英文名: Anandamide

描述: Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide) 是一种免疫调节剂，通过大麻素受体 CB1 和 CB2 起作用，还通过中枢神经系统中的其他靶点起作用，如 GPR18/GPR55。

体外活性: Anandamide, acting via CB2 receptors, alleviates lipopolysaccharide (LPS)-induced neuroinflammation in rat primary microglial cultures. Endocannabinoids, especially Anandamide (AEA), can activate numerous other receptors like PPARS, TRPV1, and GPR18/GPR55 [1].

体内活性: Anandamide is an endocannabinoid binding both CB1R and CB2R. To evaluate the impact of CBR activation on whole-body glucose homeostasis, glucose tolerance is assessed after a single intraperitoneal Anandamide injection (10 mg/kg). The increase in glycemia in response to glucose ingestion is considerably smaller in mice treated with Anandamide compared with control. It is associated with an improvement of glucose tolerance as illustrated by the AUC0-2h calculations[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : 10 mg/mL (28.77 mM)
DMSO : 55 mg/mL (158.26 mM)


关键字: Transient receptor potential channels | Inhibitor | inhibit | Alzheimer’s disease | Candida albicans | anti-fungal | anti-adhesive | cervical epithelial cells | Endogenous Metabolite | G protein-coupled receptor 55 | Streptozotocin | hVSMC | N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide | HeLa cells | GPR55 | TRP Channel | Anandamide | Cannabinoid Receptor | endocannabinoid | Peroxisome proliferator-activated receptors | Fungal | PPAR | Tau Protein

相关产品: A-836339 | CB 65 | GW 833972A | CB1R antagonist 1 | AM1241 | BML-190 | EHP-101 | GP 1a | Pregnenolone | Pregnenolone acetate

相关库: Human Endogenous Metabolite Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Human Metabolite Library | GPCR Compound Library | Human Endogenous Metabolite Compound Library Plus | Natural Product Library for HTS | NO PAINS Compound Library | Bioactive Compound Library | Natural Product Library

花生四烯酸乙醇胺 T14046信息由TargetMol中国为您提供，如您想了解更多关于花生四烯酸乙醇胺 T14046报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途