8-溴-cGMP钠 T14064

Product Introduction
Bioactivity


英文名: 8-Bromo-cGMP sodium

描述: 8-Bromo-cGMP sodium 是一种 PKG 激活剂， 是 cGMP 的膜渗透性类似物。8-Bromo-cGMP sodium 具有缓解疼痛和血管舒张作用，可显着抑制 Ca2+ 宏观电流，抑制高 K+ 刺激的胰岛素释放。

体外活性: 8-Bromo-cGMP sodium (1 µM-0.1 mM) can inhibit acetylcholine-induced increases in intracellular calcium concentrations.[1]8-Bromo-cGMP sodium (1-100 μM; 16 h) induces the synthesis of HO-1 protein in a concentration-dependent fashion.[2] 8-Bromo-cGMP sodium (1-100 μM; 8 h) increases the resistance of LLC-PK1 cells to CsA toxicity in concentration-dependently.[2]

体内活性: 8-Bromo-cGMP sodium (0.3, 1, 3 nM; intrathecal administration; 10 min before the test; male ICR mice) significantly increases the tail-flick latency in Vincristine-treated mice to the level observed in vehicle-treated naive mice in dose-dependently.[3] 8-Bromo-cGMP sodium (10 mg/kg; iv; single dose) results in vasodilator responses in WT littermates and eNOS-Tg mice in C57BL/6 background (19-35 g).[4]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 90.0 mg/mL (201.8 mM)


关键字: 8 Bromo cGMP sodium | 8-Bromo-cGMP sodium | 8BromocGMP sodium

相关产品: 4-Hydroxycinnamamide | NecroX-5 | Calcicludine | Alismol | AY 77 | (R)-(+)-Bay-K-8644 | Atagabalin HCl | CRAC intermediate 1 | SKF-96365 hydrochloride | Periplocymarin

相关库: Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Tyrosine Kinase Inhibitor Library | Bioactive Compound Library

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