化合物9-ING-41 T14066

Product Introduction
Bioactivity


英文名: 9-ING-41

描述: 9-ING-41 是基于马来酰亚胺的 ATP 竞争性和选择性的糖原合酶激酶-3β 抑制剂，IC50为 0.71 μM。它显著导致癌细胞的细胞周期停滞，自噬和凋亡，具有增强化疗药物抗肿瘤作用的潜力，有抗癌活性。

体外活性: 9-ING-41 (2, 4 μM; 48 hours) decreases neuroblastoma cell viability induces apoptosis[2]. 9-ING-41 (1, 2 μM; 24 hours) is a potent cell cycle-blocking agent for lymphoma cells[2]. 9-ING-41 (0.1-1 μM) inhibits GSK-3 leading to a decreased expression of the NF-κB target XIAP and significant apoptosis in neuroblastoma cells as shown by PARP cleavage, an apoptosis marker[1]. 9-ING-41 (0.5, 1.0, 1.5, 2.0 μM) inhibits the proliferation rate of all TCL and MCL lines with concentrations as low as 1.0 mM[2].

体内活性: In a mouse model of MCL, 9-ING-41 (40 mg/kg/every other day; for 17 days) has single-agent antitumor activity [2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 97 mg/mL (239.89 mM)


关键字: cycle | GSK-3 | cell | inhibit | 9ING41 | 9-ING-41 | Apoptosis | Inhibitor | Glycogen synthase kinase 3 | 9 ING 41 | arrest | Glycogen synthase kinase-3 | anticancer | Autophagy | GSK-3β | activity

相关产品: SB 202190 | BG45 | SCH79797 dihydrochloride | ON1231320 | Taurodeoxycholic acid | WP1066 | Cambinol | SC-43 | PCI-34051 | M3541

相关库: Drug Repurposing Compound Library | Anti-Neurodegenerative Disease Compound Library | Anti-Cancer Drug Library | Inhibitor Library | Anti-Cancer Clinical Compound Library | Kinase Inhibitor Library | Anti-Cancer Active Compound Library | Metabolism Compound Library | Stem Cell Differentiation Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途