化合物 T14095 T14095

Product Introduction
Bioactivity


英文名: ACH-806

描述: ACH-806 is an NS4A antagonist. It can inhibit Hepatitis C Virus (HCV) replication with an EC50 of 14 nM.

体外活性: ACH-806 is an NS4A antagonist which can inhibit Hepatitis C Virus (HCV) replication with an EC50 of 14 nM. The levels of labeled NS3 and NS4A immunoprecipitated by anti-NS3 antibody are apparently reduced after the treatment of ACH-806, which also induces significant decreases of NS3 and NS4A and promotes p14 formation in the parental replicon cells but not in the ACH-806-resistant replicon cells[1]. ACH-806 treatment results in significant reductions of both NS3 and NS4A in the transfected cells. This finding is reminiscent of ACH-806-treated replicon cells in which the amounts of NS3 and NS4A are also both decreased. The total amount of NS3 in the ACH-806-treated sample is reduced by ~6-fold (100/16) and causes a reduction of NS4A-bound NS3 ~29-fold (261/9).

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: ACH-806 | GS 9132 | ACH806 | GS-9132 | ACH 806

相关产品: Paritaprevir | RO-9187 | NS5A-IN-2 | MK-0608 | PSI-6130 | Sofosbuvir impurity K | BILB-1941 | Filibuvir | ITX5061 | Dehydrojuncusol

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途