化合物 T14145 T14145
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 220619-73-8 | ¥12,800.00 | 询底价 |
50 mg | 220619-73-8 | ¥16,800.00 | 询底价 |
100 mg | 220619-73-8 | ¥21,500.00 | 询底价 |
Product Introduction
Bioactivity
英文名: AGN194204
描述: AGN194204 (IRX4204) is inactive against RAR and is an orally active and selective RXR agonist with Kd values 0.4 nM, 3.6 nM and 3.8 nM and EC50s of 0.2 nM, 0.8 nM and 0.08 nM for RXRα, RXRβ and RXRγ, respectively. AGN194204 has anti-inflammatory and anticarcinogenic actions[1][2].
体外活性: AGN194204 (NRX194204; 1 μM; 72 hours; SK-BR-3 human breast cancer cells) treatment induces apoptosis in breast cancer cells[1]. AGN194204 (NRX194204; 0-100 nM; 24 hours; E, RAW cells) treatment blocks the ability of lipopolysaccharide and tumor necrosis factor-α to induce the release of nitric oxide and interleukin 6 and the degradation of IKBα in RAW264.7 macrophage-like cells[1].
体内活性: AGN194204 (NRX194204; 30-60 mg/kg; oral administration; daily; for 15 weeks; female A/J mice) treatment significantly reduces the number and size of tumors on the surface of the lungs. It reduces the total tumor volume per slide by 64% to 81% compared with the control group[1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: IRX 4204 | IRX-4204 | AGN-194204 | VTP-194204 | AGN194204 | NRX-194204 | VTP194204 | NRX 194204 | AGN 194204
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途