阿奇霉素二水合物 T1419

Product Introduction
Bioactivity


英文名: Azithromycin hydrate

描述: Azithromycin hydrate (CP-62993 dihydrate) 是一种大环内酯抗生素，可研究细菌感染。

细胞实验: THP-1 cells (106 cells in 1 mL RPMI medium, without antibiotics, growth factors or serum) are seeded in each well of 24-well plates and allowed to settle for 1 hour. Next, 50 μL of the test compound is added followed by 50 μL of LPS (final concentration of 10 μg/mL). After 24h (37°C and 5% CO2) the supernatants and cell pellets are collected (1200 rpm, 5 min). THP-1 cell viability is tested using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). MTT is dissolved at 2 mg/mL in PBS and aliquots are stored at -20°C. The MTT assay is performed according to the suppliers instructions. Absorbance of MTT converted into formazan is measured at a wavelength of 570 nm with background subtraction at 630 nm.

体内活性: Azithromycin (50 mg/kg) has no effect on bronchoalveolar lavage inflammatory parameters and LDH levels in a mouse model of asthma exacerbation. Azithromycin induces neither general inflammatory parameters nor LDH release in a mouse model of asthma exacerbation, and augments expression of interferon-stimulated genes and the pattern recognition receptor MDA5 which is sufficient to reduce viral load, but not RIG-I in exacerbating mice[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 10 mg/mL (12.73 mM)
DMSO : 50 mg/mL (63.69 mM)
Ethanol : 93 mg/mL (118.5 mM)


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相关产品: Oxytetracycline | Acetylspiramycin | Kanamycin A | Tigecycline | KKL-10 | Gentamicin sulfate | Erythromycin ethylsuccinate | Amikacin sulfate | Methacycline hydrochloride | Chloramphenicol

相关库: FDA-Approved Drug Library | Drug Repurposing Compound Library | Anti-Cancer Drug Library | Saccharide and Glycoside Natural Product Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Approved Drug Library | Microbial Natural Product Library | Orally Active Compound Library | Anti-infective Natural Product Library | Anti-Infection Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途